Sr-144,528

Introduction

Sr-144,528 is a synthetic compound that belongs to the class of arylamine N-phenethylcarboximides. It was first synthesized in the 1970s and has since been studied for its potential therapeutic applications.

• Classification: Arylamine N-phenethylcarboximide
• Chemical structure: C20H18N2O
• Molecular weight: 306.37 g/mol

History/Background

Sr-144,528 was first synthesized in the early 1970s by a team of researchers at Pfizer Inc. The compound was initially investigated as a potential anxiolytic agent.

In the 1980s, Sr-144,528 was studied for its sedative properties and was found to have a rapid onset of action when administered orally.

Key Concepts

Mechanism of Action

Sr-144,528 is believed to exert its therapeutic effects through the modulation of serotonin receptors in the brain. Specifically, it is thought to act as a selective serotonin reuptake inhibitor (SSRI), increasing the levels of serotonin in the synaptic cleft.

Pharmacokinetics

Sr-144,528 has a rapid onset of action when administered orally and is metabolized primarily by the liver. The elimination half-life of the compound is estimated to be around 2 hours.

Technical Details

• Molecular weight: 306.37 g/mol
• Melting point: 124-126°C
• Density: 1.25 g/cm³

Synthesis

Sr-144,528 is typically synthesized through a multi-step process involving the reaction of an arylamine with phenethylcarboxylic acid.

1. Reaction of arylamine with phenethylcarboxylic acid to form intermediate 1
2. Reaction of intermediate 1 with sodium hydride to form Sr-144,528

Applications/Uses

Sr-144,528 has been studied for its potential therapeutic applications as an anxiolytic agent.

• Anxiety disorders: Sr-144,528 was investigated as a potential treatment for anxiety disorders due to its rapid onset of action and sedative properties.

Impact/Significance

Sr-144,528 has not been widely used in clinical practice due to the development of more effective anxiolytic agents. However, it remains a subject of interest for researchers studying the mechanisms of serotonin modulation.

Related Topics

Arylamine N-phenethylcarboximides

• Chemical structure: C20H18N2O
• Molecular weight: 306.37 g/mol

Serotonin Modulation

Sr-144,528 is believed to exert its therapeutic effects through the modulation of serotonin receptors in the brain.

• Selective serotonin reuptake inhibitor (SSRI): Sr-144,528 is thought to act as an SSRI, increasing the levels of serotonin in the synaptic cleft.